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812 Conifer Road
Augusta, GA, 30909
United States


Friends of Frances is an annual marathon to promote and raise awareness for Macrocephaly-capillary malformation (M-CM). Frances Brown was diagnosed with this rare disease and has been bravely battling its challenges since birth.


About M-CM

Macrocephaly-capillary malformation (M-CM) is a multiple malformation syndrome causing body and head overgrowth and abnormalities of the skin, vascular system, brain and limbs.  The disorder has recently (June 2012) been attributed to a genetic mutation in a gene called PIK3CA.  The mutation in M-CM is thought to always occur after cell division begins and is therefore very unlikely to be inherited.  A mutation that happens at this stage results in different percentages of cells being affected in different individuals, so there is significant variability in how severely each individual is affected.

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